Kolluri Laboratory research efforts are directed toward understanding the molecular mechanisms of carcinogenesis, discovering molecular targets that are selective for cancer, developing agents that are selectively toxic to cancer cells, and devising optimal combinations of therapeutic agents aimed at different molecular pathways for the prevention and treatment of cancer. We are currently focusing our efforts to (i) Develop small molecules to treat Bcl-2 overexpressing cancers and (ii) Therapeutic targeting of the Ah Receptor in cancer and (iii) Activation of cell cycle regulators to suppress cancer cell growth.