About Ken van Holde
Kensal (Ken) E. van Holde was a pioneering force in physical biochemistry and a cornerstone of our department from 1967 until his passing in 2019. A University Distinguished Professor and internationally respected scientist, Ken helped shape our program from its earliest days.
Ken brought exceptional expertise in ultracentrifugation, CD, and other biophysical methods—tools he used to uncover fundamental truths about chromatin structure. His team’s groundbreaking work helped reveal that core histones exist in equal amounts and that DNA wraps around nucleosome core particles like “beads on a string.” This insight transformed our understanding of how genetic material is organized and earned Ken election to the National Academy of Sciences. Remarkably, the centrifuge he installed decades ago is still in use today.
Beyond his scientific impact, Ken was a devoted educator, mentor and author. His scholarship includes the classic text Chromatin, the monograph Oxygen and the Evolution of Life, and influential textbooks such as Principles of Physical Biochemistry and the widely used Biochemistry.